myDGR

myDGR provides annotation of diversity-generating retroelements (DGR) systems, including reverse transcriptase (RT), target gene,
template repeat (TR), and variable repeat (VR, which is part of the target gene). Additional features including GC-rich inverted repeats (forming hairpin structure) and accessory gene will also be reported if applicable.

A showcase: DGRs detected in Thiohalocapsa PB-PSB1 (GenBank GCA_016745215.1) (myDGR report) (paper: Targeted hypermutation of putative antigen sensors in multicellular bacteria (PNAS 2024))

See a quick example: DGR predicted in Bordetella-phage-BPP-1, and more examples in the Demo Page

Use myDGR:

• Submit sequences to the server for prediction: Prediction
• Look up pre-calculated DGR systems: Collection or Genome
• Retrieve existing jobs: MyJob
• Check out The Help page for more explanations.
• For more information about RTs associated with DGR systems, checkout myRT

Cite us:

• Fatemeh Sharifi and Yuzhen Ye, MyDGR: A server for identification and characterization of diversity-generating retroelements. NAR, gkz329, https://doi.org/10.1093/nar/gkz329, 2019 (paper) (bibtex)

Acknowledgement (This work was supported by NSF grants DBI-1262588 & NIH grant 1R01AI108888 )

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